This research aims to reveal the difficulties faced by the tenth grade students in learning material information technology in secondary schools official in Lattakia province. To achieve this goal has been prepared questionnaire consisting of 40 items divided into (5) domains. Applied to the (248) students in the tenth grade in Lattakia province The results showed that most of the difficulties faced by the students were as follows: In the field of physical difficulties: number of computers are limited compared to the large number of students. In the field of educational difficulties related to the course: the lack of modern educational programs that help in learning faster. Difficulties in the field of teaching style: Do not give students enough freedom to practice computers well. Difficulties in related to evaluation ways: interested in the theoretical evaluation at the expense of practical one. In the area of personal difficulties: the lack of a computer in my house - There are no differences between males and females about the difficulties they face in learning the information technology course. - There are no differences between rural students and students in the city about the difficulties they face in learning the information technology course.