Decreasing serum lipids is still blocked by chemical drugs which have many side effects, and to achieve a safe medicine, this study aims to investigate the act of aqueous extracts of dried and fresh Zingiber officinale roscoe at tow doses on the levels of total cholesterol, HDL high-density cholesterol, LDL low-density cholesterol, and TG triglycerides in rat with hypercholesterolemia, resulting from hypothyroidism, caused by propyltheouracil PTU.