The research aims to identify the factors affecting the profitability of commercial banks, arranged according to their relative importance, and the comparison between commercial banks, public and private about the factors that affect their profitability. The research descriptive analytical method. One of the most important results: 1 - affected the profitability of commercial banks Syrian combination of factors can be classified in two categories: internal factors and external factors. 2 - different factors affecting the profitability of commercial banks in the relative importance of, and the most influential factor was economic and political conditions, and employing resources, legislation and legal and banking controls. While the age of the bank and the number of bank employees less influential factor. 3 - There are no statistically significant differences between commercial banks, public and private in the internal and external factors that affect their profitability.