Importance and aims of the research Biomechanics science is interested in studying the dynamic function and the movement of vital tissues depending on their mechanical properties. The main objective of this research is to design a digital model of the human femur using the engineering software specialized in medical image processing and engineering design in order to simulate the mechanical behavior. This would provide important medical information to orthopedic surgeons concerning the paths and the causes of bone fractures and deformities, and open a new perspectives in prosthetics efficiency enhancement. Materials and methods A three dimensional digital model of the femur was produced using the software DeVIDE v 9.8 for medical image processing. A surface triangular mesh was constructed and the mechanical response of the model has been simulated using Ansys 14.5. Results and discussions We have shown the steps necessary to design a computerized model of femur bone on the basis of three-dimensional X-ray images. The results showed the distribution of stresses and displacements of human femur at normal load conditions. Conclusion and recommendations It is recommended to adopt the specialized engineering software for the threedimensional simulation which can be used in different medical applications.