The Drastic method has been used to assess the potential sensitivity of the Groundwater In Lattakia basin using Arc GIS 9.2 Where the modified Drastic system has been developed by combining the land uses and its divisions with general Drastic model .As a result, final values of Drastic have been modulated into two categories "low and moderate sensitivity" It has been found that the introduction of the human criteriahas increased the potentialof the moderate sensitivity of the Groundwater. As a final result, the general content of the sensitivity map which has been establishedfor Lattakia basin, showed, the domination of low sensitivity category in the north western and the north eastern areas which has big location depths of the Groundwater and high topographic altitudes.In contrast, the moderate sensitivity category dominated in the southern areas of the study region. The latter areas which are characterized by the existence of varied human activities havelocation ofGroundwater levels close to the surface.