Compliance of treatment regimens considers one of the challenge the end-stage renal disease patients, because of its highly cost related to medication, sessions, diets and the life style modification. Objective: to assess the compliance of end-stage renal disease patients with treatment regimens. Setting: The study was carried out in all the hemodialysis departments in the governmental hospitals in Lattakia. These were Al-Assad Hospital- Public Lattakia Hospital- Military Hospital- Jablah Public Hospital- Al-Kurdaha Public Hospital- Al-Hafa Public Hospital. Subjects: the study consisted 230 patients of the hemodialysis department in the time of study from the first of November to April 2014. Tool: patients were interviewed individually to collect the necessary data using tool I, their compliance with treatment regimen were assessed using tool II. Results: only 2.17% of the patients were compliance with prescribed treatment regimen. Their compliance was affected by some factors like the hospital where they got sessions, monthly income, and with the date of beginning treatment.