The Influence of Type and Concentration of Polymer on Furosemide Release from Extended Hard Capsules


Abstract in English

The aim of the present study is to prepare extended hard capsules of furosemide using Eudragit RL, Eudragit RS and Ethyl cellulose individually and in different ratios (6,8,12 and 15%). The granules were prepared by wet granulation using isopropyl alcohol as a granulating agent and then filled into capsules. The influence of different concentrations and type of polymer was studied. The prepared capsules assessed for their physicochemical properties and in-vitro drug release studies. In vitro release data show that Ethyl cellulose has more retardation than Eudragits, and Eudragit RS retards drug more than Eudragit RL does. Furthermore, higher concentration of polymer tends to more retardation than lower concentration.

References used

CHUGH I.; NIMRATA S., Oral Sustained Drug Delivery System: An Overview. International Research Journal of Farmacy. Vol.3, 2012
UMMADI S.; SHRAVANI B. Overview on Controlled Release Dosage Form. International Journal of Pharma Sciences, Vol.3, 2013, 258-269
ROWE C. R.; SHESKEY J.P.; QUINN E. M. Handbook of Pharmaceutical Excipients, 6th ed, The Pharmaceutical Press, 2009

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