Due to it`s several properties of Trypsin as an active enzyme in treating wounds, the aim of this study was to evaluate the efficacy of this material with traditional treatments in treating dry socket. Methods:132 patients (20-65 years old) participated in this study. The patient were distributed randomly into two groups. The first group (group 1) was treated with Trypsin whereas the other (group 2) was treated with traditional technique . Patients were monitored, to asses healing process, after 24 hours, 48 hourse, and after 1 week. Results: 43,9% of group 1 and 10,6% of group 2 had no pain P<0,05,wereas 81,8% of group 1 and 43,9% of group 2 didn`t present dry socket P<0,05. Concerning infection ,7 cases of group 1 and 11 cases of group 2 had infection of soft tissue P<0,05. Conclusions :Pain, dry socket, and soft tissue infection was less in casese treated with Trypsin comparing with cases treated with traditional technique.