Facial structures, as well as their functions and correlations, have been extensively studied to expand the knowledge of craniofacial growth and development and to optimize growth predictions and proper indications of orthodontic and surgical treatments. The cranial base forms the boundaries of the craniofacial complex . The nasomaxillary complex is related to the anterior cranial base, whereas the mandible is related to its posterior portion. Therefore, the shape of the cranial base is an important factor in establishing the position of the maxilla and mandible. Aim: to investigate the relationship of cranial base with jaws rotation in adult orthodontically non-treated subjects using Cone- Beam Computed Tomography (CBCT) scan. Materials and methods: 27 Caucasian adult patients with no prior orthodontics treatment were selected (16 males, 11 females) .Cephalometric measurements determining type of jaw rotation were performed according to Björk's analysis. Pearson's Correlation Coefficient was calculated to investigate the relationship between the CBCT cranial base measurements and Cephalometric measurements determining type of jaw rotation . Results: This study reveal vary correlation between CBCT measurements of cranial base's dimensions and jaws rotation. Conclusions: There is no relationship between the cranial base morphology and Jaws rotation in adult orthodontically non-treated subjects.