This study was conducted in the village of Almetrkyah located in the southern coastal plain of Lattakia city during 2014. In order to study the effect of Cucumber mosaic virus on growth and development of two varieties of peppers, hybrid ESTAR F1 H (sweet pepper) and Demer(spicy pepper). This study included eight treatments, four treatments for each variety. Plants were mechanically inoculated in three different stages, preflowering bloom, flowering andpost-flowering stages each beside its non-inoculated control. The result should that, the appearance of Cucumber mosaic virus symptoms on infected sweet hybrid, was within four days before its appearance on inoculated spicy variety,symptoms were leaf crinkle, leaf deformation, yellow patches and plant stunting. Inoculated plants showed reduction in number of leaves, number of branches and yield. Plants in pre flowering bloom stage were more effected by virus infection in both varieties. Meannumber of leaves per plant of ESTAR F1 H hybrid were 130 in pre flowering bloom stage compared with 170 leaf/plant in the control treatment. Mean number of branches per plant of ESTAR F1 H hybrid were 43,4 branch/plant in pre flowering bloom stage compared with 56,7branch/plant in the control treatment. Total pepper production per plant was 700,8g in infected plants in preflowering bloom stage compared with 1267,5g/plant in ESTAR F1 H hybrid control. Results of Demer variety take the same results of ESTAR F1 H hybrid. The effect of virus infection on pepper plants were reduced when inoculation were done during flowering stage and post-flowering stage, differences were significant between inoculated plants in both varieties.