Purpose: We evaluated the safety of ESWL (Extracorporeal Shockwave Lithotripsy). Materials and Methods: A total of 300 patients with stones located in the kidney or the upper ureter were randomly divided into 3 groups, group A—100 who received ESWL and they do not use anticoagulation drugs and thy do not have problems with kidneys, liver or pancreas B—100 who received ESWL and they use anticoagulation drugs C—100 who received ESWL and they have one kidney. Radiologic and laboratory follow up were performed in the first week by:US –UREA-CR-ALT-AST-AMILAS. Statistical analysis was performed using the chi square test and Anova test. Results: The hematomas rate was 10.5%.Rates elevation of urea and cr was (27%, 5%). Rate elevation of alt–ast was 12%, and for amylase was 6%, without clear pathology. Conclusions: ESWL is an easy, noninvasive, safe and active management of the urinary stones, and we should be care full with some factors, which can increase its complications and decrease its activity.