This study included (163) patients admitted to the department of Surgery in Al-Assad university hospital at Lattakia , between 1/1/2010 and 31/12/2013. They all had Laparoscopic cholecystectomy due to acute cholecystolithiasis. The male patients composed (24.5%), and the female patients composed (75.5%) and the ratio of females to males was (1:3.08). In our study the age of most patients (53.4 %) was between (21-40) years. The more frequent clinical features was pain (92.6%) , fever (74.8%) and (nausea + vomiting) (72.4%). Ultrasound abdomen was done in (100%). The most intra – operative complication was perforation of gall bladder and spilled stones (3.7%) and post – operative complication was spilled bile. The conversion rate from Laparoscopic cholecystectomy to open method was (7.4%). cholecystectomy was done in (50.9%) in the first 72 hours of hospitalization and was done in (49.1 %) after the 72 hours of hospitalization. The median operating time was (72) minutes . The mean stay being (1.7) days.