A retrospective study of 55 cases (mean age 55, range 82 ـ 35 years) of Gastrointestinal stromal tumors cancer admitted at AL Assad University Hospital , Lattakia , Syria. from 1\1\2002 to 1\1\2014 for studying its :locations ,risk factors and surgical management. Stomach was the most common site for GISTs in 52.27% , small intestinal in 30.90%, rectum in 9.09% and colon in 7.27%. The most common clinical signs and symptoms were: gastrointestinal bleeding 61.8% ,abdominal pain 21.81%.the histologic prognosis was high and moderate in 72.72% of patients. Total gastrictomy was performed for one patient ,subtotal gastrictomy for 16 patients and a wedge in 11 cases. In 6 patients a segementectomy of small intestinal were performed. and in one patient a resection of the upper rectum performed.