Many complications are associated with the surgical removal of impacted third molars. One of these complications is the formation of a deep periodontal pocket distal to the second mandibular molar . Plasma Rich in Growth Factors is a material containing many growth factors Which have an essential role in wounds healing and tissue regeneration. The aim of this study was to assess the efficacy of autologous PRGF in bone regeneration techniques to prevent development of periodontal pocket at the distal root of the mandibular second molar following extraction of an impacted third molar.