Central Nervous System Relapse in Adults with Acute Lymphoblastic Leukemia


Abstract in English

Relapse of acute lymphoblastic leukemia (ALL) in the central nervous system (CNS) in adults is considered a poor prognostic feature. Few reports have analyzed this issue. The objective of this study was to estimate the experience with CNS recurrence in adult patients with ALL, then to choose the best therapy.

References used

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Evans AE, Gilbert ES, Zandstra R. The increasing incidence of central nervous system leukemia. Children’s Cancer Study Group A. Cancer. 2005;26:404–9
Ortega JA, Nesbit ME, Sather HN, Robison LL, D’Angio GJ, Hammond GD. Long-term evaluation of a CNS prophylaxis Trial—treatment comparisons and outcome after CNS relapse in childhood ALL: a report from the Children’s Cancer Study Group. J Clin Oncol 2006;5(10):1646–54

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