Frame structures contribute to resist the seismic loads. On the other hand, frames work efficiently to increase the ductility of buildings. Therefore, many techniques were used to improve the resistance against lateral loads where steel shear walls are considered to be one of these ways. This research aims to study the effect of inserting steel shear wall on the resistance of the reinforced concrete frame against earthquake loads. In this study, Finite Element Method (FEM) using Geometrically and Materially Non-Linear Analysis (GMNLA) was performed. Pushover analysis is used to explore the behavior of the steel plate in-filled reinforced concrete frame against lateral loads. Moreover, the effect of plate thickness was undertaken. On the other hand, an opening is made in this plate. Then, the influence of the position and dimension of this opening on the resistance was observed. This study shows that using a steel plate shear wall with or without opening can enhance the resistance to seismic loads significantly together with the deflection decrease.