P53:Its Role As Gardian of The Genome and in Apoptosis and Antioncogenesis
published by Damascus University
in 2012
in Dentistry
and research's language is
العربية
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Abstract in English
P53 is the guardian of genome from any alteration, its gene is called tumor suppressor gene . p53 checks
any alteration in cell cycle ,and if the alteration happened p53 resolves or shares in activation proteins
important in resolving , if the cell couldn't resolve the alteration p53 leads it to apoptosis . goingthe cell
out of this nature cycle and continuing its resistance and proliferation makes it a tumor celland that make
p53 very important study.
References used
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Hollstein M, Sidransky D, Vogelstein B,Harris C. p53 mutations in human cancers. Science 1991;253: 49- 53