Economic losses resulting from the impact of brucellosis on animals have increased, which is reflected in turn on humans. Brucella is pathogenic bacteria shared by humans and pet animals. They still pose a significant risk that threatens health and economics in Syria. Many efforts have focused to prevent the spread of brucellosis disease, by resorting to the use of vaccines prepared from Brucella strains, where now the target is preparation of vaccine components proteins of Brucella can be used as a vaccine or an improved traditional vaccine.