Chromatographic Determination of Total Benzalkonium Chloride [BAC] in Some of Ophthalmic Preparations by HPLC


Abstract in English

An analytical chromatographic method for determination of total benzalkonium chloride in eye drops preparations samples containing gentamicin sulphate, tobramicin and viscous eye drops samples containing fusidic acid has been developed.

References used

R. C. Rowe, P. J. Sheskey, M. E. Quinn; 2009. Handbook of Pharmaceutical Excipients, 6th. ed., Pharmaceutical Press, 917P. English
G. Santoni, A. Tonsini, P. Gratteri, P. Mura, S. Furlanetto, S. Pinzauti; 1993. Determination of atropine sulphate and benzalkonium chloride in eye drops by HPLC, International Journal of Pharmaceutics, Volume 93, Issues 1–3, PP. 239-243
M. Gaber, M. Hazem Abu Shawish, M. Abdalla Khedr, I. Khalid Abed- Almonem; 2012. Determination of benzalkonium chloride preservative in pharmaceutical formulation of eye and ear drops using new potentiometric sensors, Materials Science and Engineering: C, Volume 32, Issue 8, PP. 2299-2305

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