Self-medication with antibiotics is a worldwide problem and led to several problems such as antimicrobial resistance. A descriptive cross-sectional questionnaire-based study was conducted in Latakia city. Among 259 participants, 204(78.8%) reported antibiotics self-medication within past one year. Respiratory problems such as common cold were the main indication for self-medication with antibiotics (62.9%) and amoxicillin+ clavulanic acid was the most antibiotic commonly used (35.37%). The results of this study confirm that self-medication with antibiotics is a frequent problem in Latakia city.