Automated Red Cell Exchange in Sickle Cell Disease

The majority of patients with SCD receive transfusions at some point in their life. Transfusion can be simple transfusion or exchange transfusions which offer better control of blood volume and viscosity. Such transfusions are most readily accomplished via automated red cell exchange. Evaluate the results of our experience in applying the technique of selective cell separation by continuous flow (Cytapheresis) for automated red cell exchange for patients with sickle cell anemia to reduce the level of hemoglobin S (HbS) in certain cases, especially in preparation for major surgery.