Classified locality Yeasts have been culturing in plantology department at the Faculty of Science-University of Damascus, from genera of Pichia, Candida, Geotrichum, Rhodotorula, Phaffia on solid Czhapek agar medium, and after incubated in appropriate conditions their colonies showed evidence of different colors to produce a variety of pigments. Then it cultured in liquid Czhapek medium to increase biomass and the genera producing endocellular pigment separated from the medium by filtration with added ethanol on them and blasting cells by ultrasonic waves to get a pigment, while the genera producing exocellular pigment is separated about the liquid medium also by filtration but the solvent was added to the medium containing the pigment.