The objective of this study was to Compare between The Effect Of secondary closure and Rubber Drain post surgical Extraction to Impacted Lower Third Molars On edema, pain, and trismus level. Clinical trial included symmetric bilateral 40 lower third molar in 20 patients whose ages between18-45 years. The sample was randomly divided into two groups: Group 1: included 20 molars ,a 4–5 mm wedge of mucosa adjacent to the second molar was removed to obtain secondary healing. Group 2: included 20 molars ,a rubber drain was inserted into the extraction socket near the buccal fold after surgery and left for 72h. Edema, pain and trismus were measured On first , third and seventh day following surgery. The findings showed a significant difference between the effect of secondary closure and rubber drain on the Edema, pain and trismus after surgical Extraction of Impacted Lower Third Molars. The Edema, pain and trismus were less in secondary closure group.