In this study, 24 patients with posterior skeletal cross-bite were treated at Orthodontics Department-Faculty of Dentistry in Hama University. Hyrax expansion device was applied in all patients and the results were assessed after active expansion period. Cone beam computed tomography radiograph were taken at the assessment times. Results showed that the midpalatal suture width has increased significantly at all measured areas. The results revealed that significant tipping in the canines , premolars and molars was recorded in this study.