The aim of this study was diagnosis and conservative treatment of Pyometra in dogs with antiprogestins (such as Aglepriston) and prolactin inhibiting (Cabergoline) associated with synthetic PGF2α (Cloprostinol) will replace ovariohysterectomy. Twenty-three dogs (8,5 ± 3,2 years old and 5-35 kg weight) from different breeds with know breeding history and open or closed type of Pyometra, were used in this study. All dogs underwent a general and gynecological examination including Ultrasonography.