The inhibition role of protein kinase C (PKC) in programmed cell death of Leishmania tropica promastigotes
published by Aِl-Baath University
in 2014
in
and research's language is
العربية
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Abstract in English
The aim of this work was determining the role of
Protein kinase C (PKC) signaling pathway in apoptosis of
Leishmania tropica promastigotes, through studying effects of PKC
specific inhibitor Staurosporine (STS) on the parasite. Our results
showed that treated L. tropica with Staurosporine was
enough to inhibit PKC pathway completely, while viability test
showed that the concentration of STS to inhibit cell growth by 50%
(IC50 = 2.146μM).
References used
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Vaux, D.L. and A. Strasser, 1996. The molecular biology of apoptosis. Proc Natl Acad Sci U S A, 93(6): p. 2239-44