Forests regeneration is considered as an important and urgent need in all their existence areas for protecting environment and supporting biodiversity. Accordingly, the research aims to study the most important influencial factors in natural regeneration in Jabatta Al Khashab wood reserve and recommend requirements for promoting these societies to an apogee, define the hindering obstacles, and to set adequate plans to protect and develop this area. For realizing this goal, several botanic field inspections (Relevés) were performed through the time span lasted from May 2010 March 2011, through which, natural regeneration process of different botanic species was followed up in the reserve, in particular woody flora such as both oak species trees (Quercus sp), neapolitan (Crataegus azarolus) terebinth, broom and others. The research revealed a very weak natural regeneration of oaks (Quercus sp) in general and its attendant tree in particular. It was realized that major role in that is attributed to unnatural factors namely environmental tourism and diversified human activities. The research revealed that diversified human activity in the area, though declaring it as a natural reserve, is not only the regeneration hinderer but even the regeneration inhibitor. This activity has an explicit impact on botanic grassy and woody species regeneration decline and species population retreat due to overgrazing, overloading, random harvesting of nourishing and herbal plants, fire lighting in the reserve, picnickers' activities, and other factors.