This study includes a full analysis of climatic, vegetation, and topographical factors in Nabe Matta preserve (Drekish Region – Tartous Governorate – Syria), which is considered as the most important factors affecting forest fires. The data were collected for each fire and analyzed by statistical programs (SPSS) and (EXCEL), and the relationship between these multiple factors and the phenomenon of recurrence of fire in one area (fire risk region) was studied. Then the data and the results of the analysis and multi relationship had been studied within the geographic information system software (GIS) to obtain the map of fire risk region, as well as results from topographic maps (1:50.000), aerial photographs (1:25.000), and the needed maps were designed for the study such as (slope map - aspect map - vegetation cover map - infrastructure map - fire risk region map),then places of monitoring towers and centers of rapid intervention in high-risk areas have been proposed for the occurrence of fires. These maps are considered as warning systems and with it we can predict the probability of any fire in the Preserve when the appropriate conditions are provided for it.