Al-Kabeer Al-Shemale river rises from Aqraa Mountain and coastal mountains, it is considered one of the largest rivers in the coastal area.Its catchment area is 1097 km2, and empties into the sea to the southern of Lattakia.The study aims to determine the impact of climate change on the river discharge. Since the rainfall is the major factor in the runoff formation in the river catchment, the rainfall changes have been studied in climatic stations located within the catchment and its surroundings, and for a period of time exceeding thirty years. The study found that the general trend of rainfall change and runoff with time is decreasing, declining rainfall values ranged in the studied stations between (0.4-12.5) mm per year, and the runoff reached 0.08m3/s in the year. A mathematical equation, predict river discharge after knowing the values of daily precipitation, has been concluded.