The objective of this study is to examine the relationship between accounting information and stock prices of listed companies on Damascus Stock Exchange in order to assess the usefulness of accounting information for investor’s decisions. Price Regression Model has been used to measure the explanatory power of book value and earnings in relation to variations in stock prices during the period from 2009 to 2012. The findings show that (1) preliminary financial reports provide useful accounting information for investors (2) earnings per share has a stronger impact on stock prices than book value (3) in comparison with final financial reports, balance sheet accounting information were more useful; whereas, income statement information were less useful.