Chemical Synovectomy with Rifmpicin Injections in the Knee in Hemophilic Patients
published by Damascus University
in 2009
in Medicine
and research's language is
العربية
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Abstract in English
Background: Many options are available for the treatment of synovitis or target joint in hemophilia to prevent recurrent bleeding and further joint destruction when conservative therapy fails such as chemical synovectomy. Chemical synovectomy with Rifampicin has been used for many years in several clinical trials with good results and without serious complications.
Objective :evaluate the safety and the efficacy of this procedure in the Syrian hemophilic patients.
Conclusion: chemical synovectomy with rifampicin is a good treatment, cheap and safe in hemophilic patients.
References used
Mannucci, PM, Tuddenham, EG. The hemophilias--from royal genes to gene therapy. N Engl J Med 2001; 344:1773
Rosendaal, F, Aledort, LM, et al. Definitions in hemophilia. Recommendation of the scientific subcommittee on factor VIII and factor IX of the scientific and standardization committee of the International Society on Thrombosis and Haemostasis. Factor VII and Factor IX Subcommittee. Thromb Haemost 2001; 85:560
Nienhuis, AW. Development of gene therapy for blood disorders. Blood 2008; 111:4431
Shetty, S, Vora, S, Kulkarni, B, et al. Contribution of natural anticoagulant and fibrinolytic factors in modulating the clinical severity of haemophilia patients. Br J Haematol 2007; 138:541
Van Dijk, K, Van Der, Bom JG, Fischer, K, et al. Do prothrombotic factors influence clinical phenotype of severe haemophilia? A review of the literature. Thromb Haemost 2004; 92:305