Nonmelanoma skin cancer (NMSC) is the most common diagnosed malignancy. The NMSC consists of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The purpose is to determine and evaluate the potential clinical or pathological changes of these lesions in the last years. A group of archived cases of (NMSC) diagnosed in (1998-1999-2000) and in (2009-2010-2011) at a large university hospital in Lattakia (Alassad university hospital) was studied. The studied pathologic attributes included the histological type of BCC (nodular, superficial, infiltrating) and histological grade of SCC ( well, moderate, and poorly differentiated). Demographic features included age, sex and location. The results are: Basal cell carcinoma was the predominant form of NMSC over the two study periods. BCC/SCC rate was higher than that reported before 9 years. The most common location is the head and neck. Most cases were diagnosed among patients aged (60-80) years. Both the nodular type of BCC and the well differentiated SCC had the higher rates. These rates have changed in time but the nodular BCC remained the most common type with slight decrease (P=0.31) followed by superficial (P=0.11) and then infiltrating (P=0.28). As for the well differentiated SCC, it remained the first with a significant increase in moderately differentiated SCC (P=0.009). The majority of patients were males except for the last years; the majority of SCC cases were females.