Renal diseases are an important medical subject because of their prevalence, so to know frequency of glomerular diseases in Syria and compare it with international studies we studied 261 renal biopsies over a period (1/1/2007–31/12/2012), in Al Assad Hospital of the University in Damascus, investigated by light microscopy immunofluorescence. One hundred and ten cases (59.8%) were primary glomerulonephritis from 184 cases of glomerular disease focal/segmental glomerulosclerosis FSGS was the most common type of primary glomerulonephritis found (30.9%) of primary glomerulonephritis), followed by membranous nephropathy(MN) in 29.1 % , IgAnephropathy (IgAN) in 10%, then membranoproliferative glomerulonephritis (MPGN) and minimal change disease(MCD) 9.1% and, crescentic glomerulonephritis (CerGN) in 6.4% and finally postinfectious glomerulonephritis (PIGN) 5.5 % of the secondary glomerulonephritis were (74 cases constituting 40.2% of the biopsies) lupus nephritis(LN) was the most frequently diagnosed disease (85.1% of secondary glomerulonephritis) diabetic nephropathy (DN) was found in 8.1% of cases amyloidosis (AMD) in 6.8%.