This study is conducted to assess the role of hepcidin as a biomarker of iron status in haemodialysis patients. The study included88 patients who had end-stage renal disease ( ESRD), and were treated with haemodialysis in the Department of Renal Medicine in Al-Assad University Hospital in Lattakia. Serum hepcidin and ferritinlevelswere measured, and transferrin saturation (TSAT) was calculated after measuringthe total iron binding capacity (TIBC), these markers were then attached with iron and compared to know the hardest correlation. Results show that all the patients had high serum hepcidin levels,there was a statistically significant relation between iron and hepcidin, where P-VALUE smaller than 0.05, this relationship was inversal, hardly 40% the stongest correlation. Conclusion: These findings suggest that the increased hepcidinin haemodialysis patients may contribute to abnormal ironregulation and erythropoiesis, and may be a novel biomarker of iron status and erythropoietin resistance.