This research was conducted at Izraa research station of The General Commission for Scientific Agricultural Research during the growing season 2010/2011 to study the performance of six durum wheat varieties at early growth stage under water deficit stress. The experiment was designed using randomized complete block design with three replication. The statistical analysis results of the experiment clearly showed genetic variations among cultivars under water stress. Drought stress caused a depression in all studied traits. Mean yield decreased in average 31.7 %. The number of spiks/ m2 was the most trait affected by drought stress, It decreased in average 29.1% while biological yield decreased in average 24.26%. It was observed that the number of spikes per m2 was the highest in the variety Hourani (191) and the highest number of grain per spike (34.1) whereas the variety Bohouth7 and the variety hourani recorded the highest thousand grain weight (40.5 g). The statistical analysis results showed that the variety Cha5 a achieved the highest grain yield per m2 (239.4 g), whereas, the variety Bohouth7 recorded the lowest grain yield per m2 (182.8 g), under water deficit stress conditions.