The aim of this research is to study the most important physical, chemical and microbial changes in several kinds of infant milk available in local markets. The milk samples were studied in conditions similar to those used by mothers when they prepare infant milk bottles at their houses. The results showed that moisture content increased in all samples from approximately 1% to 3.2-4.4% after storage for 9 days. Acidity increased considerably from 0.14% to 0.2%. The results showed that peroxide value passed the allowable limits (0.25) and reached about (0.47) in samples stored for 9 days at room temperature. However, the value for samples stored in the refrigerator ranged between (0.25-0.29). The free acidity number of fat for all samples specially the refrigerated ones was within the natural limits (<0.5). Chromatographic analyses showed apparent differences in fatty acid percentages between the kinds of milk. The rate of lenoleic acid (C 18-2 ) decreased during storage in all samples and in all conditions. Soluble nitrogen increased in all samples at the end of storage and the highest value was 0.49% in Nido milk samples. The solubility of milk samples was checked during storage and was found to decrease very little ( 1%). The total count of aerobic bacteria showed that all samples conform to the Syrian standards (No. 197, 1996) during the first six days of storage, but they passed the upper limits at the end of storage. However, all samples were free of pathogenic microbes .