Bone involvement in systemic mastocytosis


Abstract in English

Systemic mastocytosis (SM) is a rare malignant neoplasia, which can create bone complications. The most frequent of those is secondary osteoporosis, sometimes responsible for fractures, especially of the rachis. We report the case of a 53 year-old woman with 3 non-traumatic lombar fractures, leading to the diagnosis of SM, after bone marrow trephine biopsy. We describe the different types of bone involvement in MS, their physiopathology, their diagnosis and treatment, with help of a bibliographic review.

References used

Karine B, Atteintes osseuses des mastocytoses systématiques, Revue du rhumatisme monographies 80 (2013) 120-124
Travis WD, Li CY, Bergstralh EJ, Yam LT, Swee RG. Systemic mast cell disease: analysis of 58 cases and literature review. Medicine. 1988;67:345–68
Chiappetta N, Gruber B. The role of mast cells in osteoporosis.Semin Arthritis Rheum. 2006 Aug;36(1):32–6
Tharp MD. Southwestern Internal Medicine Conference: the spectrum of mastocytosis. Am J Med Sci. 1985;289:119–32
Suzuki K, Lees M, Newlands GF, Nagase H, Woolley DE. Activation of precursors for matrix metalloproteinases 1 (interstitial collagenase) and 3 (stromelysin) by rat mast-cell proteinases I and II. Biochem J. 1995 Jan 1;305(Pt 1):301–6

Download