The research aims to studying the relationship the depression to self esteem in second grade secondary in Homas, and to study the differences in depression in the research variables(sex, specialization), and to study the differences in self esteem in the research variables(sex, specialization). students from the second grade secondary. and it was used the following tools: 1 - a measure –Blal Alkhateeb- 2 - Beck measure of depression, after that she has tested reliability, It was followed the descriptive analytical method.