the fibroma's correlation with age, gender and the location of lesion, and then to conduct an analytical study of the collagenous and mineralized constituents between the lesions of the maxilla and mandible for the patients of the faculty of dentistry, Damascus university. Methods & Materials: Our study covered 36 patients aged 9 – 40 years, (average 24.5 years old), 12 males and 24 females. Central cemento-ossifying fibroma was diagnosed and treated at maxillofacial surgery department, the oral histology and oral pathology department, faculty of dentistry, Damascus university, between 2004 and 2008. Biopsies were studied after they had been stained with hematoxylin and eosin. The analytical tables were made using SPSS program, issue 13.0 and Chi square test for Sig<0.05. Results: The clinical examination of the tumor showed hard swelling covered by normal mucosa. The proportion of tumors in females was 2:1 for males in the third decade of life. 58.3 of lesion were in the mandible mainly in premolars and molars. The histological study showed fibrous connective stroma of bundles of collagenous fibers including fibroblasts and mineralized materials either osseous, osteoid or cementoid. Bundles of collagenous fibers formed 55.6% of fibrous connective. The ratio of laminar bone trabeculae was varied between 40% for the maxilla and 67% for the mandible. Osteoid material existed by 60% in the maxilla and 33% in the mandible. 90.5% of mandibular tumor compared with 73% of that of the maxilla were surrounded by a true complete connective capsule. The statistics study showed a correlation between the mineralized materials and the location of lesion Sig<0.05. Conclusion: central cemento-ossifying Fibroma appeared much greatly in females of thirties and it trended to defeat the mandible more than the maxilla. There was an important correlation between the mineralized materials and the location of lesion.