The aim of this study was to evaluate the affecting factors of Buffalo milk production in Al- Ghab Plain. The data were collected according to the farmers during the season of 2009-2010. The effect of parturition season, dry period and calving interval were studied. The results showed that the mean milk production was 934,96 kg with 8.1% fat and 4.85% protein. The lactation period was 180-240 days, the dry period was 120-180 days and the calving interval mean was 420 days. Our results indicated that the quantity of buffalo milk in Syria was low because of the short lactation period, the long dry period and the long calving interval. But it could be possible to improve the buffalo milk production by the better rasing conditions and genetic improvement.