Determining the best location is a complex process that faces decision makers. In the City of Tartous, Syria, this problem springs while selecting the best location for wastewater treatment plant (WWTP) because of the large number of criteria and constrains and the uncertainty in expert's judgments. To solve this problem, we designed a frame work containing multi-criteria decision making (MCDM) technique that is fuzzy analytic hierarchy process (FAHP) to handle the uncertainty situations and geographical information system (GIS) to determine the best location. In this paper, the FAHP idea was developed to calculate weights of the criterias, the GIS was used to overlay and generate criteria and suitability maps. The study ends with a map of the best sites for constructing wastewater treatment plants by extended aeration method in Tartous region in Syria.