This paper deals with electromagnetic(EM) interaction in anisotropic medium which is characterized by spatial different permitivity in (x,y,z)coordinates. The EM-analysis is a modern method in micro- and nano-scopic technology. This interaction was modulated and simulated by CST software (Computational System Technology) that confirms the behavior of EM propagation and scattering in an isotropic medium.It could be also used in data transmission, device construction and scattering analysis