Research aimed at identifying the role of knowledge management in improving institutional performance of the employees at the University of Damascus, and to identify significant differences in the answers the sample search to identify knowledge management according to variables research: (academic rank, years of experience, job description), has adopted a researcher on the descriptive analytical approach, and used the search tool: (questionnaire knowledge management), where the research sample included 243 teaching faculty member at the University of Damascus. Among the most important findings of the research: There are significant differences between the average Answers members of the research sample to identify knowledge management variable according to academic rank in favor of individuals who have the academic rank of professor. There are significant differences between the average Answers members of the research sample to identify knowledge management variable according to years of experience for the benefit of individuals who have years of experience (21 + years). There are significant differences between the average Answers members of the research sample to identify knowledge management variable according to the job description for the benefit of individuals who had the job description (Dean of the Faculty, Vice-Dean). In light of the research findings ,the researcher proposes the following: 1. Create a house of expertise and decision support at the university through the creation of an constantly updated database and information systems that everyone works in its preparation that provide the employees and departments with the necessary quantitative and qualitative information in the appropriate time and appropriate way, as one of the most important processes of knowledge management. 2. The necessity of taking the three-dimensional key of knowledge: hardware , software, knowledge resources in addition to the human recourses , the knowledge generator and maker and the most important element in this integrated system, which is the substantive equivalent of the physical system.