This study tries to assess the potential anti-atherosclerotic role of adiponectin. It includes 54 patients at Al-Assad University Hospital in Lattakia, who are candidates for catheterization, and control group of 25 individuals. Serum adiponectin levels have been measured in both groups, and levels of hs-CRP have been also measured in both groups and compared with adiponectin levels. Catheterization has been done to the patients group and the results of angiography are categorized to mild, moderate, and severe coronary artery disease (CAD) according to the SYNTAX SCORE The study concludes that serum adiponectin levels are higher in patients with mild CAD(23.86 μg/ml) compared to patients with moderate to severe CAD (13.62 μg/ml);(p=0.001<0.05). The average serum adiponectin levels in control group was (17.1μg/ml). There was no statistically significant of the relation between the concentration of hs-CRP and the concentration of adiponectin .However, there was a statistically significant difference between the average concentration of hs-CRP in the patients group (7.1 mg/l) and the control group (2.7 mg/l); (P=0.003<0.05).