Introduction: oral infection is one of the most common disturbances in the intensive care units ICUs, especially with the critical intubated patients. Application of oral care policy works as a very important action in preventing the infection. ADHA improved that using of Chlorhexidine Gloconate 0.12% and Povidone Iodine 1% solutions in oral care can contribute to preventing oral infection. Goal: The aim of the present study was to investigate the effect of applying oral care policy to the oral infection rate with intubated patients. Materials and Methods: The study was conducted at the intensive care units of AL-Basel Hospital (Tartous), a convent sample of 45 patients. Beck Oral Assessment Scale was used to assess the oral status and results after 72 hours of applying oral care policies for the two experimental groups and the control groups. Results: our results demonstrate the important of applying oral care policy, rate of infection decreased in the first control group (p= 0.000*) which received first oral care policy procedures (Chlorhexidine Gloconate 0.12%); it was (Povidone Iodine 1%) in the second control group (normal saline 0.9%) in the last control group. Conclusions and Recommendations: our present study results recommend applying oral care policy (Chlorhexidine Gloconate 0.12%, Povidone Iodine 1%) because of its affect in preventing oral infections for critical intubated patients.