This is s retrospective analytic study of 27 cases of esophagojejunal anastomotic leakage after gastrectomy for gastric cancer during the period 1\1\1997 -1\1\2014 at AL Assad University Hospital, Lattakia, Syria. The most common risk factors of leakage were: factors related to the patient: (age, sex, hemoglobin level, total protein level, and albumin level); factors related to surgical resection: (combined resection of other organs, mechanical and manual esophago-jejunostomy) and factors related to the tumor: (tumor stage, tumor location, and ends of anastomosis free of tumor)