Low birth weight and premature infant need complementary treatment intervention to promote optimal clinical outcome and to decrease the immediate adversities and developmental deficits associated with prematurity and intensive care unit environment. The purpose of this study was to investigate the effect of complementary treatment program on the clinical outcome for preterm and low birth weight infant. The study was conducted at the pediatric intensive care units of AL-Assad hospital and maternal &child hospital (lattakia). The sample was divided into two groups of 20 infants experimental croup and 10 infant control croup with gestational age less than 36 weeks at birth, birth weight less than 2500g and more than 1500 g, and no congenital anomalies. The clinical outcome was significantly improved in clinical outcome, while no change in the control group. The experimental group had significantly weight gain, higher scores for awake state and motor activity than the control group. Significantly greater fidgeting or crying, and increased motor activity. The results of this study advice to apply complementary treatment therapy because its affect in improve clinical outcome. Nursing staff can use complementary treatment to promote the infant's capability to respond positively to his environment and to provide developmental support for healthy premature infants