Preparation of prolonged release matrix tablets of verapamil and comparaison with coated ones


Abstract in English

The purpose of this study was to prepare prolonged release tablets of verapamil: matrix and coated tablets, because of the importance of these systems in drug delivery and improving the patient compliance and therapeutic efficacy .Different formulations were prepared by using different release-modifiers polymers (EURL100 and EURS100). Direct compression technique was used to prepare coated tablets while matrix tablets were prepared by wet granulation and direct compression methods. The prepared formulations were evaluated in terms of their precompression parameters, physical characteristics, dissolution test and in vitro drug release kinetic studies. The results showed that matrix tablets containing 7.5or10% of EuRS100 and EuRL100 respectively and that coated tablets prepared by using coating solution (15%) which was applied about 120(in case of EuRS100) or 280 (in case of EuRL100) times were the best. These tablets released about 90-95% of verapamil within 24h

References used

KHACHANE, K. N.; BANKAR, V. H.; GAIKWAD, P. D.; PAWAR, S. P. Novel Sustained Release Drug Delivery System: Review. International Journal of Pharmaceutical Research and Development. 3(12), 2012, 1-14
ANCSEL, H. C.; ALLEN, L. V.; POPOVICH, N. G. Modified release dosage forms and drug delivery systems In: Pharmaceutical dosage forms and drug delivery systems, 7th Edn, Lippincott, Williams C Wilkins, Philadelphia. 1997, 229-243
MODI, Sh. A.; GAIKWAD, P. D.; BANKAR, V. H.; PAWAR, S. P. Sustained Release Drug Delivery System : A Review. International Journal of Pharma.Research and Development. 2(12), 2011, 147-160
Kabir et al.,2009
Bhagwat DA, Kawtikwar PS, Sakarkar DM. Sustained release matrices of verapamil HCl using glyceryl monosterate and stearic acid. Res J Pharm Tech 2008;1:405-09

Download