In this paper, we develop Sindhi subjective lexicon using a merger of existing English resources: NRC lexicon, list of opinion words, SentiWordNet, Sindhi-English bilingual dictionary, and collection of Sindhi modifiers. The positive or negative sentiment score is assigned to each Sindhi opinion word. Afterwards, we determine the coverage of the proposed lexicon with subjectivity analysis. Moreover, we crawl multi-domain tweet corpus of news, sports, and finance. The crawled corpus is annotated by experienced annotators using the Doccano text annotation tool. The sentiment annotated corpus is evaluated by employing support vector machine (SVM), recurrent neural network (RNN) variants, and convolutional neural network (CNN).