This paper describes TenTrans large-scale multilingual machine translation system for WMT 2021. We participate in the Small Track 2 in five South East Asian languages, thirty directions: Javanese, Indonesian, Malay, Tagalog, Tamil, English. We mainly utilized forward/back-translation, in-domain data selection, knowledge distillation, and gradual fine-tuning from the pre-trained model FLORES-101. We find that forward/back-translation significantly improves the translation results, data selection and gradual fine-tuning are particularly effective during adapting domain, while knowledge distillation brings slight performance improvement. Also, model averaging is used to further improve the translation performance based on these systems. Our final system achieves an average BLEU score of 28.89 across thirty directions on the test set.